Personalized Supplement


Every individual has a unique microbiome like a fingerprint. The members of this microbiome can be influenced by our diet and environment. If the biome is not in balance, bacteria that cause negative effects can dominate and, dysbiosis, mental and physical pathologies can occur. To correct the dysbiosis, bacteria that hurt the body need to be removed and bacteria that help the body need to be introduced or provided for in order that they stay. 5R Plan (Remove, reduce, reuse)



Prebiotics

  • Inulin & GOS : Not ready to introduce yet

Probiotics
  • Lactobacillus and Bifidobacteria probiotics
  • Supplement with S. Boulardii
  • Orthospore IG (Dr. prescribed, and I had no idea about it)
Enzymes
  • FODMATE (Dr. prescribed, and I had no idea about it)
Antibiotics (This is beyond the scope of what a regular person can do without a prescription, however the data is beneficial) After reading, it seems rifamaxin seems to leave the postive bacteria while eliminating the bacteria that create negative metabolites)
  •  We demonstrated that rifaximin, while not altering the overall structure of the human colonic microbiota, increased bifidobacteria and led to variation of metabolic profiles associated with potential beneficial effects on the host.
Rifaximin modulates the colonic microbiota of patients with Crohn's disease: an in vitro approach using a continuous culture colonic model system (2022). Available at: https://academic.oup.com/jac/article/65/12/2556/752363 (Accessed: 19 August 2022).

Psychobiotics (adding this for fun)

Potential Psychobiotic

Dosage of psychobiotic

Observation of psycho effect

Study model

B. longum 1714

1×109 CFU/day by the stick with probiotic strains mixed into milk and drunk each morning for 4 weeks

Decreased stress and enhanced memory

Clinical/N=22 healthy male volunteers

L. rhamnosus (JB-1)

1×109 CFU/day as capsule for 4 weeks

Decreased stress-related behaviors, corticosterone release, and altered expression of central GABA* receptors

Clinical N=29 healthy male volunteers

L. reuteri ATG-F4

1×107 CFU/day as drinking water for 4 weeks

Anti-infammatory efects interleukin (IL)- 10 and serum dopamine level signifcantly increased

Animal model N=10 male mice

Pedicoccus pentosaceus WS11, L. plantarum SK321, L. fermentum SK324, L. brevis TRBC 3003, B. adolescentis TBRC 7154, Lactococcus lactis subsp. lactis TBRC 375

6×109 CFU/day as cell pellets were administered daily via oral gavage for 14 days

Reduced anxiety level, increased locomotor function, improved short-term memory

Animal model N=7 male Wistar rats

L.gasseri CP2305 

1×1010 CFU/day mixed with acid milk beverages for 5 weeks

Improved the sleep quality, efect on the growth of fecal Bacteroides spp. involved in the intestinal infammation

Clinical N=21 male and N=11 female healthy students

L. plantarum PS128

1×1010 CFU/day as pellet for 2 weeks by oral administration

Reduced tic-like behaviors

Animal model N=10 male Wistar rat

L. plantarum PS128

3×1010 CFU/day as capsule for 4 weeks

Improve opposition/defance behaviors in ASD children

Clinical N=80 children (7–15 age) with ASD

L. plantarum PS128

1×1010 CFU/day as pellet by oral gavage for 4 weeks

Reduced motor defcits, elevated corticosterone, and prevention of Parkinson’s disease

Animal model N=18 male mice

Multi-strain probiotic (Bacillus coagulans Unique IS2, L. rhamnosus UBLR58, B. lactis UBBLa70, L. plantarum UBLP40, B. breve UBBr01, B. infantis UBBI01)

1×109 CFU/capsule 2 times a day for 28 days

Reduction in depression anxiety stress scale and state-trait anxiety inventory

Clinical N=80 student (63 female and 17 male)

L. plantarum 90sk and B. adolescentis 150 

0.5 mL/day of the mixture includes 1×107 CFU of B. adolescentis and 1×108 CFU of L. plantarum by oral gavage for 14 days

Reduced depressive-like behavior 

Animal model N=48 male mice with anxiety-like behavior and measures of despair

L. rhamnosus JB-1

1×109 CFU/day by oral treatment for 14 days 

Antidepressant efects

Animal model N=46 male mice with anxiety-like behavior and measures of despair

L. casei W56, L. acidophilus W22, L. paracasei W20, B. lactis W51, L. salivarius W24, L. lactis W19, B. lactis W52, L. plantarum W62, and B. bifdum W23

3000 mg daily oral treatment for 6 months

Normalized the gut-microbiome composition, reduced infammation and gastrointestinal discomfort, and increased body weight

Clinical N=60 patients with anorexia nervosa (13–19 years)



Synbiotics:

A prebiotic is "a selectively fermented ingredient that allows specific changes, both in the composition and/or activity in the gastrointestinal microflora that confers benefits upon host well being and health", whereas synergistic combinations of pro- and prebiotics are called synbiotics


de Vrese, M., & Schrezenmeir, J. (2008). Probiotics, prebiotics, and synbiotics. Advances in biochemical engineering/biotechnology, 111, 1–66. https://doi.org/10.1007/10_2008_097


Herbal Supplements suggested for current conditions based on GI ASSAY: (put them into context, what do they do what are they for)

  • deglycyrrhizinated licorice
    • In vitro study on glabridin and glabrene (flavonoids present in licorice root) revealed anti-Helicobacter pylori (H. pylori) activity, and the licorice extract has also shown significant beneficial effect on all forms of H. pylori infection
      • "An Extract of Glycyrrhiza glabra (GutGard) Alleviates Symptoms of Functional Dyspepsia: A Randomized, Double-Blind, Placebo-Controlled Study". Www.Ncbi.Nlm.Nih.Gov, 2022, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3123991/. Accessed 18 Aug 2022.
  • mastic gum
    •  It has been demonstrated that a nutritional supplement, Chios Mastic Gum, can improve liver function and partially normalize gut microbiota composition in mice with advanced NAFLD
      • "Mastiha (Pistacia lentiscus) Improves Gut Microbiota Diversity, Hepatic Steatosis, and Disease Activity in a Biopsy‐Confirmed Mouse Model of Advanced Non‐Alcoholic Steatohepatitis and Fibrosis". Www.Ncbi.Nlm.Nih.Gov, 2022, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003480/. Accessed 18 Aug 2022.
  • methylmethionine sulfonium chloride
    • Cabbage Juice
    • Early studies recognized the effectiveness of raw cabbage juice in normalizing gastric and intestinal functioning. Glutamine and methionine derivatives present in the juice are believed to be the active principals. Specific attention has been focused on methionine S-methyl sulfonium (MMS) in the chlorinated form. Traditionally, this compound (MMS) has been referred to as “Vitamin U”,
      • "The Use Of Vitamin U For Gastric Ulcer Recovery". Www.Clinicaleducation.Org, 2022, https://www.clinicaleducation.org/resources/reviews/the-use-of-vitamin-u-for-gastric-ulcer-recovery/. Accessed 18 Aug 2022.
  • vitamin C
  • zinc carnosine
    • ZnC, at concentrations likely to be found in the gut lumen, stabilises gut mucosa. Further studies are warranted.
    • We have shown that ZnC, which is currently commercially available in health food stores, stimulates several aspects of gut mucosal integrity.
    • the standard recommended dose is around 37.5 mg once or twice daily.
  • bismuth citrate
    • seems to be hard to source, pepto bismol?
  • berberine
  • goldenseal
    • antimicrobial herb?
  • oil of oregano
    • antimicrobial herb?
  • grape extract
    • In the study of Wang et al. (11), grape seed extract rich in polyphenols increase the abundance of non-pathogenic bacteria in the gut, contributing to the improvement of gut function and IBD symptoms.

  • Chinese goldthread extract

  • yerba mansa extract
  • caprylic acid
  • garlic oil
  • uva ursi or olive leaf extract
  • Glutamine
  • Essential fatty acids
  • Colostrum or immunoglobulins 
  • GI mucosal support with glutamine

Anti Fungal

Anti Microbials

DGL Licorice
https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-2006-961498