Dysbiosis
Dysbiosis Summary
GI ASSAY TEST RESULTS - Comprehensive info
Facts:
Dysbiosis is often defined as an “imbalance” in the gut microbial community that is associated with disease. This imbalance could be due to the gain or loss of community members or changes in relative abundance of microbes.
A dysbiosis can be defined as a reduction in microbial diversity and a combination of the loss of beneficial bacteria such as Bacteroides strains and butyrate-producing bacteria such as Firmicutes10 and a rise in pathobionts12 (symbiotic bacteria that become pathogenic under certain conditions), including Proteobacteria, which encompasses gram-negative Escherichia coli.
Dysbiosis (2022). Available at: https://www.sciencedirect.com/topics/medicine-and-dentistry/dysbiosis (Accessed: 12 August 2022).
Issue:
Dysbiosis detected in my biome (more info to come)
Rule:
Application:
Probiotics
The Food and Agriculture Organization (FAO) of the United Nations and the World Health Organization (WHO) have defined probiotics as “live microorganisms that confer a beneficial effect on the health of the host when administered in adequate amounts.”2 This definition has been expanded to require that probiotic organisms used in food must be capable of surviving passage through the gut and tolerant of gastric juices and exposure to bile. In addition, probiotic organisms must be safe and effective and maintain their effectiveness and potency for the duration of the shelf-life of the product.
Prebiotics
In 2007, Roberfroid79 defined a prebiotic as “a selectively fermented ingredient that allows specific changes, both in the composition of and/or activity in the gastrointestinal microflora that confers benefits upon a host’s well-being and health.” This definition means that the ingredients of prebiotics should not be metabolized by a human host’s cells and may only be metabolized by members of the gut microbiota considered to be important to gut health, such as the lactobacilli and bifidobacteria. The finer implications of this definition mean that the prebiotic ingredient should be able to travel through the majority of the GIT to move to a position in close physical proximity to its targeted bacterial cells. Prebiotics must be sufficiently resistant to gastric acidity, hydrolysis by mammalian enzymes, and gastrointestinal absorption such that a quantity great enough to stimulate growth of targeted bacteria reaches the large intestine.79 Roberfroid79 suggested that only 2 food ingredients, inulin and galactooligosaccharides (GOSs), fulfill these criteria.
wheat, onion, bananas, garlic, and chicory
Synbiotics
When probiotics and prebiotics are administered simultaneously, the combination is termed a synbiotic. Synbiotics have been proposed as increasing the levels of beneficial bacteria such as subspecies of Bifidobacterium and Lactobacillus, with the result being that the increased level of total anaerobes induces an increased production of SCFAs in the gut. The prebiotic in the synbiotic mixture improves the survival of the probiotic bacteria and stimulates the activity of the host’s endogenous bacteria, and administration of synbiotics can result in elevated bifidobacterial numbers due to the prebiotic component.
Antibiotics
Considering the growing evidence of the central role of the gut microbiota in intestinal dysbiosis, a paucity of data exists regarding treatment with antibiotics. Despite this weak evidence, their use has a long tradition. One of the more recently developed antibiotics to treat gastrointestinal diseases is rifaximin, a broad-spectrum, low-absorption antibiotic that reaches high fecal concentrations, making it an excellent therapeutic agent that is currently approved for treating traveller’s diarrhea.98,99 The effectiveness of rifamixin for treating a variety of chronic gastrointestinal diseases has also been demonstrated in several small-scale studies. Two randomized, double-blind, placebo-controlled trials indicated that rifamixin may improve IBS symptoms,100,101 and further trials show efficacy in patients with UC102 and CD.103
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4566455/
Conclusion:
the potential for probiotics to offer benefits in health improvement and disease-risk reduction in areas such as obesity, metabolic disease, and brain and neural function merely attests to the understanding that the gut has a role in human physiology. This role is much more profound than simply the digestion and assimilation of food, and the gut microbiome, as an integral, inseparable, and highly active component of the human GIT, must also play a significant role.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4566455/